Transgenic Activation of Ras in Neurons Promotes Hypertrophy and Protects from Lesion-Induced Degeneration

Ras is a universal eukaryotic intracellular protein integrating extracellular signals from multiple receptor types. To investigate its role in the adult central nervous system, constitutively activated V12-Ha-Ras was expressed selectively in neurons of transgenic mice via a synapsin promoter. Ras-tr...

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Detalhes bibliográficos
Main Authors: Heumann, Rolf, Goemans, Christoph, Bartsch, Daniela, Lingenhöhl, Kurt, Waldmeier, Peter C., Hengerer, Bastian, Allegrini, Peter R., Schellander, Karl, Wagner, Erwin F., Arendt, Thomas, Kamdem, Rigobert H., Obst-Pernberg, Kirstin, Narz, Frank, Wahle, Petra, Berns, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2000
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150671/
https://ncbi.nlm.nih.gov/pubmed/11134081
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