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Ras-dependent pathways induce obstructive hypertrophy in echo-selected transgenic mice

To overcome the genetic and interindividual variability frequently noted in complex phenotypes, we used echocardiographic selection to develop a substrain of myosin light chain (MLC)–Ras (RAS) transgenic mice with an enhanced ventricular hypertrophic phenotype. These echo-selected mice were then com...

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Detalhes bibliográficos
Main Authors: Gottshall, Kim R., Hunter, John J., Tanaka, Nobuaki, Dalton, Nancy, Becker, K. David, Ross, John, Chien, Kenneth R.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC20789/
https://ncbi.nlm.nih.gov/pubmed/9114056
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