Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families.

Previous work has indicated a role for p53 in cell cycle control, genomic stability and cellular responses to DNA-damaging agents. However, few data are available for human fibroblasts heterozygous for defined germline mutations in TP53. We report studies on 25 strains derived from 12 families with...

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Bibliographic Details
Main Authors: Boyle, J. M., Mitchell, E. L., Greaves, M. J., Roberts, S. A., Tricker, K., Burt, E., Varley, J. M., Birch, J. M., Scott, D.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1998
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150396/
https://ncbi.nlm.nih.gov/pubmed/9649131
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