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Metronidazole (flagyl) and misonidazole (Ro-07-0582): reduction by facultative anaerobes and cytotoxic action on hypoxic bacteria and mammalian cells in vivo.

The toxic actions of the "nitro" radiosensitizers, metronidazole and misonidazole on the bacteria E. coli B/r and Serratia marcescens have been investigated under anareobic and aerobic conditions. The rates of reduction of the drugs by suspensions of these bacteria as well as by suspension...

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Main Authors: Basag, S. H., Dunlop, J. R., Searle, A. J., Willson, R. L.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 1978
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2149379/
https://ncbi.nlm.nih.gov/pubmed/354677
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