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Distribution and tumour cytotoxicity of the radiosensitizer misonidazole (Ro-07-0582) in C57 mice.

The distribution and clearance of misonidazole (MIS = Ro-07-0582) were studied in C57 mouse tissues and in transplants of Lewis lung tumour. The half life of the drug in blood after a dose of 1 mg/g i.p. was 3 h. Some tissues, such as liver, were found to have consistently low MIS levels, and this w...

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Detalhes bibliográficos
Main Authors: Pedersen, J. E., Smith, M. R., Bugden, R. D., Peckham, M. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1979
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2009917/
https://ncbi.nlm.nih.gov/pubmed/444398
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