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The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity

The Helicobacter pylori toxin VacA causes vacuolar degeneration in mammalian cell lines in vitro and plays a key role in peptic ulcer disease. Two alleles, m1 and m2, of the mid-region of the vacA gene have been described, and the m2 cytotoxin always has been described as inactive in the in vitro He...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Pagliaccia, Cristina, de Bernard, Marina, Lupetti, Pietro, Ji, Xuhuai, Burroni, Daniela, Cover, Timothy L., Papini, Emanuele, Rappuoli, Rino, Telford, John L., Reyrat, Jean-Marc
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1998
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21487/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9707626/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.17.10212
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