The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity

The Helicobacter pylori toxin VacA causes vacuolar degeneration in mammalian cell lines in vitro and plays a key role in peptic ulcer disease. Two alleles, m1 and m2, of the mid-region of the vacA gene have been described, and the m2 cytotoxin always has been described as inactive in the in vitro He...

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Dettagli Bibliografici
Autori principali: Pagliaccia, Cristina, de Bernard, Marina, Lupetti, Pietro, Ji, Xuhuai, Burroni, Daniela, Cover, Timothy L., Papini, Emanuele, Rappuoli, Rino, Telford, John L., Reyrat, Jean-Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1998
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC21487/
https://ncbi.nlm.nih.gov/pubmed/9707626
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