Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

Here we report that in staurosporine-induced apoptosis of HeLa cells, Bid, a BH3 domain containing protein, translocates from the cytosol to mitochondria. This event is associated with a change in conformation of Bax which leads to the unmasking of its NH(2)-terminal domain and is accompanied by the...

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Main Authors: Desagher, Solange, Osen-Sand, Astrid, Nichols, Anthony, Eskes, Robert, Montessuit, Sylvie, Lauper, Sandra, Maundrell, Kinsey, Antonsson, Bruno, Martinou, Jean-Claude
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 1999
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148190/
https://ncbi.nlm.nih.gov/pubmed/10085289
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