Intermediate-affinity LFA-1 binds α-actinin-1 to control migration at the leading edge of the T cell

T lymphocytes use LFA-1 to migrate into lymph nodes and inflammatory sites. To investigate the mechanisms regulating this migration, we utilize mAbs selective for conformational epitopes as probes for active LFA-1. Expression of the KIM127 epitope, but not the 24 epitope, defines the extended confor...

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Hlavní autoři: Stanley, Paula, Smith, Andrew, McDowall, Alison, Nicol, Alastair, Zicha, Daniel, Hogg, Nancy
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2147999/
https://ncbi.nlm.nih.gov/pubmed/18079697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601959
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