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Intermediate-affinity LFA-1 binds α-actinin-1 to control migration at the leading edge of the T cell
T lymphocytes use LFA-1 to migrate into lymph nodes and inflammatory sites. To investigate the mechanisms regulating this migration, we utilize mAbs selective for conformational epitopes as probes for active LFA-1. Expression of the KIM127 epitope, but not the 24 epitope, defines the extended confor...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2147999/ https://ncbi.nlm.nih.gov/pubmed/18079697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601959 |
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