Regulation of cyclooxygenase-2 (COX-2) expression in human pancreatic carcinoma cells by the insulin-like growth factor-I receptor (IGF-IR) system

Both the insulin-like growth factor-I receptor (IGF-IR) and cyclooxygenase-2 (COX-2) are frequently overexpressed in pancreatic cancer. We hypothesized that IGF-IR is directly involved in induction of COX-2 and sought to investigate signaling pathways mediating this effect. Pancreatic cancer cells (...

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Bibliografiske detaljer
Main Authors: Stoeltzing, Oliver, Liu, Wenbiao, Fan, Fan, Wagner, Christine, Stengel, Kathrin, Somcio, Ray J., Reinmuth, Niels, Parikh, Alexander A., Hicklin, Daniel J., Ellis, Lee M.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2147684/
https://ncbi.nlm.nih.gov/pubmed/17950526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2007.09.009
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