Regulation of Hypoxia-Inducible Factor-1α, Vascular Endothelial Growth Factor, and Angiogenesis by an Insulin-Like Growth Factor-I Receptor Autocrine Loop in Human Pancreatic Cancer

Activation of the insulin-like growth factor-I receptor (IGF-IR) was recently shown to modulate angiogenesis by up-regulating the expression of vascular endothelial growth factor (VEGF). We hypothesized that inhibiting IGF-IR function would inhibit angiogenesis and growth of pancreatic cancer in viv...

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Main Authors: Stoeltzing, Oliver, Liu, Wenbiao, Reinmuth, Niels, Fan, Fan, Parikh, Alexander A., Bucana, Corazon D., Evans, Douglas B., Semenza, Gregg L., Ellis, Lee M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2003
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868239/
https://ncbi.nlm.nih.gov/pubmed/12937141
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