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Specificity in substrate binding by protein folding catalysts: tyrosine and tryptophan residues are the recognition motifs for the binding of peptides to the pancreas-specific protein disulfide isomerase PDIp.

Using a cross-linking approach, we recently demonstrated that radiolabeled peptides or misfolded proteins specifically interact in vitro with two luminal proteins in crude extracts from pancreas microsomes. The proteins were the folding catalysts protein disulfide isomerase (PDI) and PDIp, a glycosy...

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Bibliographische Detailangaben
Hauptverfasser: Ruddock, L. W., Freedman, R. B., Klappa, P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2000
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144619/
https://ncbi.nlm.nih.gov/pubmed/10794419
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