The b' domain provides the principal peptide-binding site of protein disulfide isomerase but all domains contribute to binding of misfolded proteins.

Protein disulfide isomerase (PDI) is a very efficient catalyst of folding of many disulfide-bonded proteins. A great deal is known about the catalytic functions of PDI, while little is known about its substrate binding. We recently demonstrated by cross-linking that PDI binds peptides and misfolded...

Full description

Saved in:
Bibliographic Details
Main Authors: Klappa, P, Ruddock, L W, Darby, N J, Freedman, R B
Format: Artigo
Language:Inglês
Published: 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170442/
https://ncbi.nlm.nih.gov/pubmed/9463371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.4.927
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items