Function of the central domain of streptokinase in substrate plasminogen docking and processing revealed by site-directed mutagenesis.

The possible role of the central beta-domain (residues 151-287) of streptokinase (SK) was probed by site-specifically altering two charged residues at a time to alanines in a region (residues 230-290) previously identified by Peptide Walking to play a key role in plasminogen (PG) activation. These m...

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Bibliographic Details
Main Authors: Chaudhary, A., Vasudha, S., Rajagopal, K., Komath, S. S., Garg, N., Yadav, M., Mande, S. C., Sahni, G.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1999
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144232/
https://ncbi.nlm.nih.gov/pubmed/10631997
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