Calcium binding to tandem repeats of EGF-like modules. Expression and characterization of the EGF-like modules of human Notch-1 implicated in receptor-ligand interactions.

The Ca(2+)-binding epidermal growth factor (cbEGF)-like module is a structural component of numerous diverse proteins and occurs almost exclusively within repeated motifs. Notch-1, a fundamental receptor for cell fate decisions, contains 36 extracellular EGF modules in tandem, of which 21 are potent...

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Main Authors: Rand, M. D., Lindblom, A., Carlson, J., Villoutreix, B. O., Stenflo, J.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 1997
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143561/
https://ncbi.nlm.nih.gov/pubmed/9336830
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