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Destabilizing loop swaps in the CDRs of an immunoglobulin VL domain.

It is generally believed that loop regions in globular proteins, and particularly hypervariable loops in immunoglobulins, can accommodate a wide variety of sequence changes without jeopardizing protein structure or stability. We show here, however, that novel sequences introduced within complementar...

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Hlavní autoři: Helms, L. R., Wetzel, R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 1995
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2142980/
https://ncbi.nlm.nih.gov/pubmed/8535243
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