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High-Affinity TCRs Generated by Phage Display Provide CD4(+) T Cells with the Ability to Recognize and Kill Tumor Cell Lines
We examined the activity of human T cells engineered to express variants of a single TCR (1G4) specific for the cancer/testis Ag NY-ESO-1, generated by bacteriophage display with a wide range of affinities (from 4 μM to 26 pM). CD8(+) T cells expressing intermediate- and high-affinity 1G4 TCR varian...
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| Asıl Yazarlar: | , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2007
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2140228/ https://ncbi.nlm.nih.gov/pubmed/17947658 |
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