High-Affinity TCRs Generated by Phage Display Provide CD4(+) T Cells with the Ability to Recognize and Kill Tumor Cell Lines

We examined the activity of human T cells engineered to express variants of a single TCR (1G4) specific for the cancer/testis Ag NY-ESO-1, generated by bacteriophage display with a wide range of affinities (from 4 μM to 26 pM). CD8(+) T cells expressing intermediate- and high-affinity 1G4 TCR varian...

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Main Authors: Zhao, Yangbing, Bennett, Alan D., Zheng, Zhili, Wang, Qiong J., Robbins, Paul F., Yu, Lawrence Y. L., Li, Yi, Molloy, Peter E., Dunn, Steven M., Jakobsen, Bent K., Rosenberg, Steven A., Morgan, Richard A.
Format: Artigo
Language:Inglês
Published: 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2140228/
https://ncbi.nlm.nih.gov/pubmed/17947658
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