Direct identification of neoantigen-specific TCRs from tumor specimens by high-throughput single-cell sequencing

BACKGROUND: Recognition of neoantigens by T cells plays a major role in cancer immunotherapy. Identification of neoantigen-specific T-cell receptors (TCRs) has become a critical research tool for studying T cell-mediated responses after immunotherapy. In addition, neoantigen-specific TCRs can be use...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Lu, Yong-Chen, Zheng, Zhili, Lowery, Frank J, Gartner, Jared J, Prickett, Todd D, Robbins, Paul F, Rosenberg, Steven A
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Immune Cell Therapies and Immune Cell Engineering
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8320258/
https://ncbi.nlm.nih.gov/pubmed/34321276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002595
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