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AMBIENT PARTICULATE MATTER INDUCES ALVEOLAR EPITHELIAL CELL CYCLE ARREST: ROLE OF G1 CYCLINS

We hypothesized that the ambient air pollution particles (PM) induce cell cycle arrest in alveolar epithelial cells (AEC). Exposure of PM (25μg/cm(2)) to AEC induced cells cycle arrest in G1 phase, inhibited DNA synthesis, blocked cell proliferation and caused decrease in cyclin E, A, D1 and Cyclin...

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Detalhes bibliográficos
Main Authors: Zhang, Jingmei, Ghio, Andrew J., Gao, Mingxing, Wei, Ke, Rosen, Glenn D., Upadhyay, Daya
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2140149/
https://ncbi.nlm.nih.gov/pubmed/17977533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.10.020
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