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Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzyme

In skeletal muscle, acetylcholinesterase (AChE) exists in homomeric globular forms of type T catalytic subunits (ACHE(T)) and heteromeric asymmetric forms composed of 1, 2, or 3 tetrameric ACHE(T) attached to a collagenic tail (ColQ). Asymmetric AChE is concentrated at the endplate (EP), where its c...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Ohno, Kinji, Brengman, Joan, Tsujino, Akira, Engel, Andrew G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21394/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689136/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9654
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