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Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau

Families bearing mutations in the presenilin 1 (PS1) gene develop Alzheimer’s disease. Previous studies have shown that the Alzheimer-associated mutations in PS1 increase production of amyloid β protein (Aβ(1–42)). We now show that PS1 also regulates phosphorylation of the microtubule-associated pro...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Takashima, Akihiko, Murayama, Miyuki, Murayama, Ohoshi, Kohno, Toshiyuki, Honda, Toshiyuki, Yasutake, Kaori, Nihonmatsu, Naomi, Mercken, Marc, Yamaguchi, Haruyasu, Sugihara, Shiro, Wolozin, Benjamin
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1998
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21391/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689133/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9637
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