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Peripheral regions of natural hammerhead ribozymes greatly increase their self-cleavage activity

Natural hammerhead ribozymes are mostly found in some viroid and viroid-like RNAs and catalyze their cis cleavage during replication. Hammerheads have been manipulated to act in trans and assumed to have a similar catalytic behavior in this artificial context. However, we show here that two natural...

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Dettagli Bibliografici
Autori principali: De la Peña, Marcos, Gago, Selma, Flores, Ricardo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC213784/
https://ncbi.nlm.nih.gov/pubmed/14532128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg530
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