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SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-α receptor
Down-regulation of activated signaling receptors in response to their ligands plays a key role in restricting the extent and duration of the signaling. Mechanisms underlying down-regulation of the type I interferon receptor consisting of IFNAR1 and IFNAR2 subunits remain largely unknown. Here we sho...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC213778/ https://ncbi.nlm.nih.gov/pubmed/14532120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg524 |
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