Hepatocyte injury in tyrosinemia type 1 is induced by fumarylacetoacetate and is inhibited by caspase inhibitors

Tyrosinemia type 1, caused by mutations in the fumarylacetoacetate hydrolase gene (Fah), is characterized by severe liver injury. We earlier developed a tyrosinemic mouse model with two genetic defects, Fah and 4-hydroxyphenylpyruvate dioxygenase (Hpd) deficiencies. Apoptosis of hepatocytes was indu...

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Hlavní autoři: Kubo, Shuji, Sun, Maosen, Miyahara, Michio, Umeyama, Kazuhiro, Urakami, Ken-ichi, Yamamoto, Tetsuro, Jakobs, Cornelis, Matsuda, Ichiro, Endo, Fumio
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1998
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC21376/
https://ncbi.nlm.nih.gov/pubmed/9689118
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