Hepatocyte injury in tyrosinemia type 1 is induced by fumarylacetoacetate and is inhibited by caspase inhibitors

Tyrosinemia type 1, caused by mutations in the fumarylacetoacetate hydrolase gene (Fah), is characterized by severe liver injury. We earlier developed a tyrosinemic mouse model with two genetic defects, Fah and 4-hydroxyphenylpyruvate dioxygenase (Hpd) deficiencies. Apoptosis of hepatocytes was indu...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kubo, Shuji, Sun, Maosen, Miyahara, Michio, Umeyama, Kazuhiro, Urakami, Ken-ichi, Yamamoto, Tetsuro, Jakobs, Cornelis, Matsuda, Ichiro, Endo, Fumio
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21376/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689118/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9552
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