A mouse model of severe von Willebrand disease: Defects in hemostasis and thrombosis

von Willebrand factor (vWf) deficiency causes severe von Willebrand disease in humans. We generated a mouse model for this disease by using gene targeting. vWf-deficient mice appeared normal at birth; they were viable and fertile. Neither vWf nor vWf propolypeptide (von Willebrand antigen II) were d...

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Hauptverfasser: Denis, Cécile, Methia, Nassia, Frenette, Paul S., Rayburn, Helen, Ullman-Culleré, Mollie, Hynes, Richard O., Wagner, Denisa D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1998
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21371/
https://ncbi.nlm.nih.gov/pubmed/9689113
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