A mouse model of severe von Willebrand disease: Defects in hemostasis and thrombosis

von Willebrand factor (vWf) deficiency causes severe von Willebrand disease in humans. We generated a mouse model for this disease by using gene targeting. vWf-deficient mice appeared normal at birth; they were viable and fertile. Neither vWf nor vWf propolypeptide (von Willebrand antigen II) were d...

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Podrobná bibliografie

Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Denis, Cécile, Methia, Nassia, Frenette, Paul S., Rayburn, Helen, Ullman-Culleré, Mollie, Hynes, Richard O., Wagner, Denisa D.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1998
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21371/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689113/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9524
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