The Tyrosine Kinase p56(lck) Mediates Activation of Swelling-induced Chloride Channels in Lymphocytes

Osmotic cell swelling activates Cl(−) channels to achieve anion efflux. In this study, we find that both the tyrosine kinase inhibitor herbimycin A and genetic knockout of p56(lck), a src-like tyrosine kinase, block regulatory volume decrease (RVD) in a human T cell line. Activation of a swelling-ac...

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Detaylı Bibliyografya
Asıl Yazarlar: Lepple-Wienhues, Albrecht, Szabò, Ildikò, Laun, Tilmann, Kaba, Nubia Kristen, Gulbins, Erich, Lang, Florian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 1998
Konular:
Regular Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2132720/
https://ncbi.nlm.nih.gov/pubmed/9531565
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