Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: Conserved helical interactions underlie the broad inhibitory activity of gp41 peptides

The gp41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) mediates membrane fusion during viral entry. The crystal structure of the HIV-1 gp41 ectodomain core in its proposed fusion-active state is a six-helix bundle. Here we have reconstituted the...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Malashkevich, Vladimir N., Chan, David C., Chutkowski, Christine T., Kim, Peter S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1998
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21304/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689046/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9134
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