The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling

Overexpression of the receptor tyrosine kinase EPH receptor A2 (EphA2) is commonly observed in aggressive breast cancer and correlates with a poor prognosis. However, while EphA2 has been reported to enhance tumorigenesis, proliferation, and MAPK activation in several model systems, other studies su...

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Autors principals: Brantley-Sieders, Dana M., Zhuang, Guanglei, Hicks, Donna, Fang, Wei Bin, Hwang, Yoonha, Cates, Justin M.M., Coffman, Karen, Jackson, Dowdy, Bruckheimer, Elizabeth, Muraoka-Cook, Rebecca S., Chen, Jin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2007
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2129239/
https://ncbi.nlm.nih.gov/pubmed/18079969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33154
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