Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy

One arising challenge in the treatment of breast cancer is development of therapeutic resistance to trastuzumab, an antibody targeting the human epidermal growth factor receptor-2 (HER2) which is frequently amplified in breast cancers. In this study, we provide evidence that elevated level of the re...

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Bibliografiske detaljer
Main Authors: Zhuang, Guanglei, Brantley-Sieders, Dana M., Vaught, David, Yu, Jian, Xie, Lu, Wells, Sam, Jackson, Dowdy, Muroaka-Cook, Rebecca, Arteaga, Carlos, Chen, Jin
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859619/
https://ncbi.nlm.nih.gov/pubmed/20028874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1845
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