The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling

Overexpression of the receptor tyrosine kinase EPH receptor A2 (EphA2) is commonly observed in aggressive breast cancer and correlates with a poor prognosis. However, while EphA2 has been reported to enhance tumorigenesis, proliferation, and MAPK activation in several model systems, other studies su...

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Main Authors: Brantley-Sieders, Dana M., Zhuang, Guanglei, Hicks, Donna, Fang, Wei Bin, Hwang, Yoonha, Cates, Justin M.M., Coffman, Karen, Jackson, Dowdy, Bruckheimer, Elizabeth, Muraoka-Cook, Rebecca S., Chen, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2129239/
https://ncbi.nlm.nih.gov/pubmed/18079969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33154
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