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A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1α
Hypoxia-inducible factor-1, HIF1, transcriptionally activates over 200 genes vital for cell homeostasis and angiogenesis. We developed a computational model to gain a detailed quantitative understanding of how HIF1 acts to sense oxygen and respond to hypoxia. The model consists of kinetic equations...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2129128/ https://ncbi.nlm.nih.gov/pubmed/16899821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.03087 |
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