Efficacy of On-Demand Asimadoline, a Peripheral Κ-Opioid Agonist, in Females with Irritable Bowel Syndrome

BACKGROUND: In experimental animal models of irritable bowel syndrome (IBS) and human studies, peripheral kappa opioid agonists have been demonstrated to decrease sensation to colonic distention. AIMS: To compare the effects of the kappa opioid agonist, asimadoline, and placebo on episodes of abdomi...

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Main Authors: Szarka, Lawrence A., Camilleri, Michael, Burton, Duane, Fox, Jean C., McKinzie, Sanna, Stanislav, Timothy, Simonson, Julie, Sullivan, Nancy, Zinsmeister, Alan R.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2128734/
https://ncbi.nlm.nih.gov/pubmed/17900994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cgh.2007.07.011
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