Thermodynamic criteria for high hit rate antisense oligonucleotide design

Antisense oligonucleotides are used for therapeutic applications and in functional genomic studies. In practice, however, many of the oligonucleotides complementary to an mRNA have little or no antisense activity. Theoretical strategies to improve the ‘hit rate’ in antisense screens will reduce the...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	Matveeva, O. V., Mathews, D. H., Tsodikov, A. D., Shabalina, S. A., Gesteland, R. F., Atkins, J. F., Freier, S. M.
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 2003
Assuntos:	Articles
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC212809/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12930948/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg710
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