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Thermodynamic criteria for high hit rate antisense oligonucleotide design
Antisense oligonucleotides are used for therapeutic applications and in functional genomic studies. In practice, however, many of the oligonucleotides complementary to an mRNA have little or no antisense activity. Theoretical strategies to improve the ‘hit rate’ in antisense screens will reduce the...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC212809/ https://ncbi.nlm.nih.gov/pubmed/12930948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg710 |
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