Elongation by RNA polymerase II on chromatin templates requires topoisomerase activity

Transcription on chromatin by RNA polymerase II (pol II) is repressed as compared with transcription on histone-free DNA. In this study, we show that human topoisomerase I (topo I) and yeast topoisomerase II (topo II), each of which relax both positive and negative superhelical tension, reverse the...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Autores principales:	Mondal, Neelima, Zhang, Ye, Jonsson, Zophonias, Kumar Dhar, Suman, Kannapiran, Madhu, Parvin, Jeffrey D.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 2003
Materias:	Articles
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC212805/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12930951/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg705
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