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Elongation by RNA polymerase II on chromatin templates requires topoisomerase activity
Transcription on chromatin by RNA polymerase II (pol II) is repressed as compared with transcription on histone-free DNA. In this study, we show that human topoisomerase I (topo I) and yeast topoisomerase II (topo II), each of which relax both positive and negative superhelical tension, reverse the...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC212805/ https://ncbi.nlm.nih.gov/pubmed/12930951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg705 |
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