Elongation by RNA polymerase II on chromatin templates requires topoisomerase activity

Transcription on chromatin by RNA polymerase II (pol II) is repressed as compared with transcription on histone-free DNA. In this study, we show that human topoisomerase I (topo I) and yeast topoisomerase II (topo II), each of which relax both positive and negative superhelical tension, reverse the...

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Опубликовано в::	Nucleic Acids Res
Главные авторы:	Mondal, Neelima, Zhang, Ye, Jonsson, Zophonias, Kumar Dhar, Suman, Kannapiran, Madhu, Parvin, Jeffrey D.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Oxford University Press 2003
Предметы:	Articles
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC212805/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12930951/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg705
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