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The crystal structures of chloramphenicol phosphotransferase reveal a novel inactivation mechanism

Chloramphenicol (Cm), produced by the soil bacterium Streptomyces venezuelae, is an inhibitor of bacterial ribosomal peptidyltransferase activity. The Cm-producing streptomycete modifies the primary (C-3) hydroxyl of the antibiotic by a novel Cm-inactivating enzyme, chloramphenicol 3-O-phosphotransf...

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Detalhes bibliográficos
Main Authors: Izard, Tina, Ellis, Jacqueline
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC212772/
https://ncbi.nlm.nih.gov/pubmed/10835366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.11.2690
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