The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

The bacterial LmrA protein and the mammalian multidrug resistance P-glycoprotein are closely related ATP-binding cassette (ABC) transporters that confer multidrug resistance on cells by mediating the extrusion of drugs at the expense of ATP hydrolysis. The mechanisms by which transport is mediated,...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	van Veen, Hendrik W., Margolles, Abelardo, Müller, Michael, Higgins, Christopher F., Konings, Wil N.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2000
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC212756/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10835349/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.11.2503
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