The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

The bacterial LmrA protein and the mammalian multidrug resistance P-glycoprotein are closely related ATP-binding cassette (ABC) transporters that confer multidrug resistance on cells by mediating the extrusion of drugs at the expense of ATP hydrolysis. The mechanisms by which transport is mediated,...

詳細記述

書誌詳細

出版年:	EMBO J
主要な著者:	van Veen, Hendrik W., Margolles, Abelardo, Müller, Michael, Higgins, Christopher F., Konings, Wil N.
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Publishing Group 2000
主題:	Articles
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC212756/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10835349/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.11.2503
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