Crystal structure of the heterodimeric complex of LXRα and RXRβ ligand-binding domains in a fully agonistic conformation

The nuclear receptor heterodimers of liver X receptor (LXR) and retinoid X receptor (RXR) are key transcriptional regulators of genes involved in lipid homeostasis and inflammation. We report the crystal structure of the ligand-binding domains (LBDs) of LXRα and RXRβ complexed to the synthetic LXR a...

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Main Authors: Svensson, Stefan, Östberg, Tove, Jacobsson, Micael, Norström, Carina, Stefansson, Karin, Hallén, Dan, Climent Johansson, Isabel, Zachrisson, Kristina, Ogg, Derek, Jendeberg, Lena
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2003
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC212723/
https://ncbi.nlm.nih.gov/pubmed/12970175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg456
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