Isolation of mutants blocked in calicheamicin biosynthesis.

Blocked mutants of Micromonospora echinospora defective in the production of the potent antitumor agent calicheamicin are described. Analysis of intermediates produced by blocked mutants indicates a branched biosynthetic pathway. Mutants that produced some, but not all, calicheamicin forms are also...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Rothstein, D M, Love, S F
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC212544/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1938969/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.173.23.7716-7718.1991
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