Isolation of mutants blocked in calicheamicin biosynthesis.

Blocked mutants of Micromonospora echinospora defective in the production of the potent antitumor agent calicheamicin are described. Analysis of intermediates produced by blocked mutants indicates a branched biosynthetic pathway. Mutants that produced some, but not all, calicheamicin forms are also...

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Detalles Bibliográficos

Publicado en:	J Bacteriol
Autores principales:	Rothstein, D M, Love, S F
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1991
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC212544/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1938969/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.173.23.7716-7718.1991
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