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A perfect correlate does not a surrogate make

BACKGROUND: There is common belief among some medical researchers that if a potential surrogate endpoint is highly correlated with a true endpoint, then a positive (or negative) difference in potential surrogate endpoints between randomization groups would imply a positive (or negative) difference i...

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Detalhes bibliográficos
Main Authors: Baker, Stuart G, Kramer, Barnett S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC212489/
https://ncbi.nlm.nih.gov/pubmed/12962545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2288-3-16
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