Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

Frizzled polypeptides are integral membrane proteins that recently were shown to function as receptors for Wnt signaling molecules. Here, we report the identification of a novel, secreted 36-kDa protein that contains a region homologous to a putative Wnt-binding domain of Frizzleds. This protein, ca...

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Main Authors: Finch, Paul W., He, Xi, Kelley, Michael J., Üren, Aykut, Schaudies, R. Paul, Popescu, Nicholas C., Rudikoff, Stuart, Aaronson, Stuart A., Varmus, Harold E., Rubin, Jeffrey S.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences of the USA 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21233/
https://ncbi.nlm.nih.gov/pubmed/9192640
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