Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors

BACKGROUND: Wnt/Wingless (Wg) signals are transduced by seven-transmembrane Frizzleds (Fzs) and the single-transmembrane LDL-receptor-related proteins 5 or 6 (LRP5/6) or Arrow. The aminotermini of LRP and Fz were reported to associate only in the presence of Wnt, implying that Wnt ligands form a tri...

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Bibliographic Details
Main Authors: Schweizer, Liang, Varmus, Harold
Format: Artigo
Language:Inglês
Published: BioMed Central 2003
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC156895/
https://ncbi.nlm.nih.gov/pubmed/12729465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-4-4
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