Peptidyl-transferase inhibitors have antiviral properties by altering programmed −1 ribosomal frameshifting efficiencies: Development of model systems

The effects of two peptidyl-transferase inhibitors, anisomycin and sparsomycin, on ribosomal frameshifting efficiencies and the propagation of yeast double-stranded RNA viruses were examined. At sublethal doses in yeast cells these drugs specifically alter the efficiency of −1, but not of +1, riboso...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Dinman, Jonathan D., Ruiz-Echevarria, Maria J., Czaplinski, Kevin, Peltz, Stuart W.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1997
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21205/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9192612/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.13.6606
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!